Sleeping Medication – Vanda

March 2, 2009

in Sleeping Pills, Vanda

Vanda does all three. In the Phase II trials, 3 different doses of VEC162 were tested against a placebo and were to found to be more effective, for all three levels. It has been found to increase sleep time up to 48 minutes, according to reports. Furthermore, it facilitates natural sleep, so there are no side effects.

WASO (Wake Up After Sleep Onset) is the insomniac’s nightmare. VEC 162 reduced this causing the user to have an efficient sleep, and the time taken to fall asleep was also reduced. In pharma – medical parlance, VEC 162 had the desired sleep onset effect and sleep maintenance effect.

How does Vanda achieve this? Unlike the other drugs that bind to GABA-A receptors, widespread in the Central Nervous System, therefore, affecting the entire nervous system, Vanda is a melatonin receptor agonist, which means it selectively binds to melatonin receptors in the brain’s ‘master clock’. It does not bind with any other receptor in the entire nervous system, thereby avoiding a sedative effect or causing depression in the entire nervous system. It dampens the alerting signal and allows accumulated sleep load to take over, very naturally. This helps treat sleep disorders safely, without the scepter of sedation, and may even help depression, which successive trials would confirm.

The good news is that Vanda will probably be sold as an uncontrolled drug, just as its predecessor Rozerem, since it has no potential for abuse and no withdrawal symptoms. There are also no uncomfortable side effects like a dry mouth or more seriously, hormonal changes. Also, Vanda betters the current favorite Rozerem in sleep maintenance and might even overtake its sales. People will probably clamor for this wonderful pill with no known side effects – but wait! The most innocuous of remedies can be abused by unthinking users.

If you do start using Vanda, please take the physician’s directions very seriously. Do not prescribe your own doses. Secondly, try not to think of the drug as a lifeline for life. Instead, look upon it as a temporary means to get over your current sleep difficulties. It is also suggested that you use it only if your lack of sleep is due to ‘physical’ causes, like an injury or post-surgery pain. If you are under stress, look to first solve your problems cerebrally, rather than just bank on drug-induced sleep. This would insure you against the most serious side effect – drug dependence, dependence more psychological than physiological. Used judiciously, there is probably no parallel to Vanda in the treatment of insomnia and other sleep disorders.

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